Summary record of the Standing Committee on the Food Chain and Animal Health. 2009;20:414–418. Wear protective gloves, protective clothing, and eye protection (P280). McCann D, Barrett A, Cooper A, Crumpler D, Dalen L, Grimshaw K, Kitchin E, Lok K, Porteous L, Prince E, Sonuga-Barke E, Warner JO and Stevenson J, 2007. Survey of benzene in foods by using headspace concentration techniques and capillary gas chromatography. Lancet, 370, 1560-1567. Report 1. An acute study with benzoic acid by gavage in male and female mice was available to the European Food Safety Authority Panel. Opinion of the Scientific Committee on Food on Benzoic acid and its salts SCF/CS/ADD/CONS/48 Final. Opinion on benzoic acid and its salts. et al., J. Chem. Qi P., Hong H., Liang X., Liu D. Assessment of benzoic acid levels in milk in China. This unpublished study showed a LD50 for males of 2,742 mg benzoic acid/kg body weight and for females of 2,565 mg benzoic acid/kg body weight. Vapor from molten benzoic acid may form explosive mixture with air. Chemical Agents and related Occupations. In its opinion on the re-evaluation of calcium carbonate (E 170) as a food additive 16), the European Food Safety Authority Panel noted that limestone may contain aluminium at concentrations up to 190 mg/kg. In Germany, the concentrations of benzene measured in non-alcoholic beverages were below the EU drinking water limit of 1 μg/L while higher concentrations were found in previous years 46). EC (European Commission), 2007b. An acute study by gavage with benzoic acid in albino rats was available to the European Food Safety Authority Panel. Benzoic acid have previously been evaluated by the EU Scientific Committee on Food (SCF) in 1994 3) and 2002 4). Commission implementing Regulation (EC) No 1035/2013 of 24 October 2013 approving benzoic acid as an existing active substance for use in biocidal products for products – types 2 and 4. The findings may thus be relevant for specific individuals within the population, showing sensitivity to food additives in general or to food colors in particular 24). EC (European Commission), 2003. WHO (World Health Organization), 2011. Held in Brussels on 20 July 2007. Toxicological evaluation of certain food additives. From the aforementioned studies, the European Food Safety Authority Panel derived an acceptable daily intake (ADI) of 5 mg/kg body weight per day (expressed as benzoic acid) using an uncertainty factor of 100. Sublimation, recrystallisation and neutralization processes have been proposed. August 2011. BENZENECARBOXYLIC ACID, BENZENEFORMIC ACID, BENZENEMETHANOIC ACID, BENZOIC ACID, BENZOIC ACID,, CARBOXYBENZENE, DRACYCLIC ACID, PHENYLCARBOXYLIC ACID, and PHENYLFORMIC ACID. Biotechnol. The Joint FAO/WHO Expert Committee on Food Additives (JECFA) has evaluated benzoic acid and its salts as food additives on a number of occasions. No studies appear to have been conducted on calcium benzoate, but the European Food Safety Authority Panel considered that calcium benzoate also dissociates into its constituents calcium and benzoate ions in the small intestine. Furthermore, anaphylaxis and urticaria have also been observed in sensitive individuals following exposure to benzoic acid and its salts at doses below the acceptable daily intake (ADI). Benzoic acid is an extensively used food preservative. It is also naturally found in cultured dairy products. Before a company can use EWG VERIFIED™ on such products, the company must show that it fully discloses the products' ingredients on their labels or packaging, they do not contain EWG ingredients of concern, and are made with good manufacturing practices, among other criteria. Overall, given supporting evidence of lack of carcinogenicity of the related substances benzyl alcohol, benzyl acetate and benzaldehyde as described by JECFA, the European Food Safety Authority Panel considered that the data are sufficient to conclude that benzoic acid and its salts did not raise concern with respect to carcinogenicity. WHO Food Additives Series, 48. EAFUS [Everything Added to Food]: A Food Additive Database. SCF (Scientific Committee on Food), 2002. SANCO – D1(2007)D/411718. Benzoic acid is generally recognised as safe. Originally the oxidation reaction was carried out at 140 °C and ca. Benzene, p. 322. Benzoic acid is a byproduct of phenylalanine metabolism in bacteria. Steinbrenner N, Löbell-Behrends S, Reusch H, Kuballa T and Lachenmeier DW, 2010. Journal für Verbraucherschutz und Lebensmittelsicherheit [Journal of Consumer Protection and Food Safety], 5, 443–452. EFSA Journal 2016;14(3):4433 https://efsa.onlinelibrary.wiley.com/doi/pdf/10.2903/j.efsa.2016.4433, SCF (Scientific Committee on Food), 1994.

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